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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP14 All Species: 33.33
Human Site: S276 Identified Species: 48.89
UniProt: P54578 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54578 NP_001032411.1 494 56069 S276 K E N Q L Q L S C F I N Q E V
Chimpanzee Pan troglodytes P60051 493 55922 S276 K E N Q L Q L S C F I N Q E V
Rhesus Macaque Macaca mulatta XP_001090667 458 52239 V248 S C F I N Q E V K Y L F T G L
Dog Lupus familis XP_537306 545 61461 S327 K E N Q L Q L S C F I N Q E V
Cat Felis silvestris
Mouse Mus musculus Q9JMA1 493 55983 S276 K E N Q L Q L S C F I N Q E V
Rat Rattus norvegicus NP_001008302 493 55958 S276 K E N Q L Q L S C F I N Q E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519267 431 48760 K221 C F I N Q E V K Y L F T G L K
Chicken Gallus gallus XP_419150 492 55612 S274 K E N Q L Q L S C F I S Q E V
Frog Xenopus laevis Q6GNI6 523 60030 L272 L I A A L D V L H R H C K G D
Zebra Danio Brachydanio rerio A6H8I0 506 58102 Q280 H C N C I I D Q I F T G G L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609377 475 53689 S263 S E N F L Q L S C F I S M D V
Honey Bee Apis mellifera XP_395043 497 56311 S271 R E E F L Q L S C F I S T E V
Nematode Worm Caenorhab. elegans Q17361 489 55859 V253 T C Y V N Q D V R F L Q T G I
Sea Urchin Strong. purpuratus XP_786966 516 58357 S277 K E T F Y Q L S C F I T Q E V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q949Y0 482 53677 K256 T E S V Y S L K C H I S H E V
Baker's Yeast Sacchar. cerevisiae P43593 499 57092 Q262 N E S D S K L Q C H I S G T T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 92.5 89.9 N.A. 96.7 96.5 N.A. 80.3 90.4 21.4 20.1 N.A. 54.6 61.7 41.9 61
Protein Similarity: 100 99.8 92.7 90.2 N.A. 98.5 98.7 N.A. 83.8 94.9 39 38.7 N.A. 71.2 80.2 61.1 76.5
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 0 93.3 6.6 13.3 N.A. 66.6 66.6 13.3 73.3
P-Site Similarity: 100 100 26.6 100 N.A. 100 100 N.A. 13.3 100 20 20 N.A. 80 80 26.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. 43.5 26 N.A.
Protein Similarity: N.A. N.A. N.A. 62.9 46.2 N.A.
P-Site Identity: N.A. N.A. N.A. 40 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 7 19 0 7 0 0 0 0 69 0 0 7 0 0 0 % C
% Asp: 0 0 0 7 0 7 13 0 0 0 0 0 0 7 7 % D
% Glu: 0 69 7 0 0 7 7 0 0 0 0 0 0 57 0 % E
% Phe: 0 7 7 19 0 0 0 0 0 69 7 7 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 7 19 19 0 % G
% His: 7 0 0 0 0 0 0 0 7 13 7 0 7 0 0 % H
% Ile: 0 7 7 7 7 7 0 0 7 0 69 0 0 0 7 % I
% Lys: 44 0 0 0 0 7 0 13 7 0 0 0 7 0 7 % K
% Leu: 7 0 0 0 57 0 69 7 0 7 13 0 0 13 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 7 0 50 7 13 0 0 0 0 0 0 32 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 38 7 69 0 13 0 0 0 7 44 0 7 % Q
% Arg: 7 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % R
% Ser: 13 0 13 0 7 7 0 57 0 0 0 32 0 0 0 % S
% Thr: 13 0 7 0 0 0 0 0 0 0 7 13 19 7 7 % T
% Val: 0 0 0 13 0 0 13 13 0 0 0 0 0 0 63 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 13 0 0 0 7 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _